Conformational analysis of alternative protein structures
نویسندگان
چکیده
منابع مشابه
Conformational analysis of alternative protein structures
MOTIVATION Alternative structural models determined experimentally are available for an increasing number of proteins. Structural and functional studies of these proteins need to take these models into consideration as they can present considerable structural differences. The characterization of the structural differences and similarities between these models is a fundamental task in structural...
متن کاملFolding kinetics for the conformational switch between alternative RNA structures.
Transitions between different conformational states, so-called conformational switching, are intrinsic to RNA catalytic and regulatory functions. Often, conformational switching occurs on time scales of several seconds. In combination with the recent real-time NMR experiments (Wenter et al. Angew. Chem. Int. Ed. 2005, 44, 2600; Wenter et al. ChemBioChem 2006, 7, 417) for the transitions between...
متن کاملProtein Stability, Folding, Disaggregation and Etiology of Conformational Malfunctions
Estimation of protein stability is important for many reasons: first providing an understanding of the basic thermodynamics of the process of folding, protein engineering, and protein stability plays important role in biotechnology especially in food and protein drug design. Today, proteins are used in many branches, including industrial processes, pharmaceutical industry, and medical fields. A...
متن کاملFast Multiple Alignment of Protein Structures Using Conformational Letter Blocks
Most approaches for protein structure alignment start from a search for similar fragments since this local similarity is necessary to the alignment even though is insufficient. In contrary to the sequence alignment, any insignificant trial alignment for structures can be detected by structure superposition and then excluded. It is then practicable to select from locally similar fragments those ...
متن کاملPrediction of protein secondary structures from conformational biases.
We use LINUS (the "Local Independently Nucleated Units of Structure"), a procedure developed by Srinivasan and Rose, to provide a physical interpretation of and predict the secondary structures of proteins. The secondary structure type at a given site is identified by the largest conformational bias during short simulations. We examine the rate of successful prediction as a function of temperat...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Bioinformatics
سال: 2007
ISSN: 1367-4803,1460-2059
DOI: 10.1093/bioinformatics/btm499